Description
Self-injury - knowing what we're looking for; self-injury and comorbid behaviours in developmental, neurological, psychiatric and genetic disorders; epidemiology of self-injurious behaviour in mental retardation - a review; treatment - current standards of care and their research implications; environmental determinants of self-injurious behaviour; functional assessment and self-restraint; the impact of functional assessment on the treatment of self-injurious behaviour; evolution of stereotypy into self-injury; incidence of self-injurious behaviour - birth to three years; self-injurious behaviour in captive macaque monkeys; dopaminergic mechanisms in self-injurious behaviour and related disorders; pemoline and other dopaminergic models of self-biting behaviour; opioids and the maintenance of self-injurious behaviour; sleep and cyclical variables related to self-injurious and other destructive behaviours; self-injury and pain - models and mechanisms; temporal and force dynamics of self-injury; lessons from Lesch-Nyhan syndrome; neuroimaging studies in Lesch-Nyhan syndrome and Lesch-Nyhan variants; age-dependent reduction of brain dopamine - relationship of neonatal reduction of dopamine to self-injurious behaviour in Lesch-Nyhan syndrome and mental retardation; a new animal model for Lesch-Nyhan syndrome - calcium channel activation with bay K 8644; replacement therapy for the treatment of Lesch-Nyhan syndrome.